Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones

A set of transition-metal-free NaI/TBHP-mediated sulfonylation cyclization reactions of methylthiolated alkynones with sulfonyl hydrazides was developed, by which various 3-sulfonylated thioflavones were prepared under mild reaction conditions. The features of this procedure included metal-free reac...

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Bibliographic Details
Published inNew journal of chemistry Vol. 44; no. 35; pp. 14786 - 1479
Main Authors Feng, Zhi-Wen, Li, Jing, Jiang, Yu-Qin, Tian, Yu, Xu, Gui-Qing, Shi, Xin, Ding, Qing-Jie, Li, Wei, Ma, Chun-Hua, Yu, Bing
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.09.2020
Royal Society of Chemistry
Subjects
Chemical reactions
Chemistry
Chemistry, Multidisciplinary
Crystallography
Functional groups
Hydrazides
Physical Sciences
Reagents
Science & Technology
Transition metals
QUINOLINE N-OXIDES
PHOSPHORYLATION
INDUCED DEOXYGENATIVE C2-SULFONYLATION
RADICAL CYCLIZATION
CASCADE
IONIC LIQUID
INHIBITORS
ARYLHYDRAZINES
DERIVATIVES
C-H
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Summary:A set of transition-metal-free NaI/TBHP-mediated sulfonylation cyclization reactions of methylthiolated alkynones with sulfonyl hydrazides was developed, by which various 3-sulfonylated thioflavones were prepared under mild reaction conditions. The features of this procedure included metal-free reaction conditions, ease of reagent handling, short reaction times, and a broad functional group tolerance. A set of transition-metal-free NaI/TBHP-mediated sulfonylation cyclization reactions of methylthiolated alkynones with sulfonyl hydrazides was developed, by which various 3-sulfonylated thioflavones were prepared under mild reaction conditions.
Bibliography:Electronic supplementary information (ESI) available. CCDC
1953609
For ESI and crystallographic data in CIF or other electronic format see DOI
10.1039/d0nj03386c
ISSN:1144-0546
1369-9261
DOI:10.1039/d0nj03386c