Organic/inorganic nanocomposites for cancer immunotherapy
Cancer immunotherapy provides an effective way to deal with cancer. Although immunotherapy strategies have shown encouraging therapeutic effects, the inherent limitations of immunotherapy, such as multiple tumor immune evasion methods, low response rate, and systemic toxicity, still hinder its clini...
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| Published in | Materials chemistry frontiers Vol. 4; no. 9; pp. 2571 - 269 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Royal Society of Chemistry
01.09.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Cancer immunotherapy provides an effective way to deal with cancer. Although immunotherapy strategies have shown encouraging therapeutic effects, the inherent limitations of immunotherapy, such as multiple tumor immune evasion methods, low response rate, and systemic toxicity, still hinder its clinical applications. In recent decades, nanomaterials have been considered promising in cancer immunotherapy since they can realize targeted delivery and interact with the immune system to induce or enhance the antitumor immune responses. Among them, organic/inorganic nanocomposites are ideal candidates for cancer immunotherapy since they could combine the advantages of both organic and inorganic components. Multifunctional organic/inorganic nanocomposites could help overcome the shortcomings of current cancer immunotherapy, and realize the combination of immunotherapy and other therapeutic strategies with synergistic antitumor effects. Herein, we review the recent progress of organic/inorganic nanocomposites designed for cancer immunotherapy. The immunotherapy strategies of nanocomposites are summarized from the perspective of achieving immune enhancement. The challenges of nanocomposites in cancer immunotherapy are also discussed.
Organic/inorganic nanocomposites are ideal candidates for cancer immunotherapy since they could combine both advantages of organic and inorganic components. |
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| Bibliography: | Prof. Fu-Jian Xu is the Executive Director of Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology. His research interests focus on functional biomacromolecules. He was a recipient of the National Science Fund for Distinguished Young Scholars (NSFC, 2013), Cheung Kong Distinguished Professor (Ministry of Education of China, 2014) and Beijing Outstanding Young Scientist Program (2018). Dr Mingqiang Hao received his PhD degree in Medicine from the Chinese Center for Disease Control and Prevention in 2017. He then worked at the Beijing Center for Disease Control and Prevention as a medical researcher for the control of HIV infection. In 2019, he joined Beijing University of Chemical Technology as a postdoctoral researcher. His current research interests focus on the applications of organic/inorganic nanocomposites and novel immune adjuvants in cancer immunotherapy. Beibei Chen received her BS degree from Beijing University of Chemical Technology in 2018. She is currently a master student under the supervision of Prof. Fu-Jian Xu and Prof. Nana Zhao at Beijing University of Chemical Technology. Her research interests focus on the design and synthesis of nanocomposites with special morphologies for cancer immunotherapy. Xiaoyi Zhao received her BS from Beijing University of Chemical Technology, China, in 2017. She is currently a PhD student under the supervision of Prof. Fu-Jian Xu and Prof. Nana Zhao at Beijing University of Chemical Technology. Her current research interests focus on the rational design and synthesis of nanocomposites and their related biomedical applications. Prof. Nana Zhao is currently a professor at Beijing University of Chemical Technology. She obtained her PhD degree in physical chemistry from Peking University, China, in 2008 under the supervision of Prof. Limin Qi, and was a postdoctoral scholar with Prof. Eugenia Kumacheva at the University of Toronto, Canada, and Prof. Lutgard De Jonghe at Lawrence Berkeley National Laboratory. She joined Beijing University of Chemical Technology, China, in 2012. She was a recipient of the National Science Fund for Outstanding Young Scholars (NSFC, 2019). Her current research focuses on the design, synthesis, and application of versatile organic/inorganic nanocomposites. |
| ISSN: | 2052-1537 2052-1537 |
| DOI: | 10.1039/d0qm00323a |