Fertility outcomes in male adults with congenital hypogonadotropic hypogonadism treated during puberty with human chorionic gonadotropin and recombinant follicle stimulating hormone

Hormone replacement therapy with testosterone for pubertal induction in boys with congenital hypogonadotropic hypogonadism (CHH) achieves virilization but not spermatogenesis. By contrast, human chorionic gonadotropin (hCG) and recombinant follicle stimulating hormone (rFSH) provides both virilizati...

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Published inJournal of paediatrics and child health Vol. 60; no. 2-3; pp. 53 - 57
Main Authors Grob, Francisca, Keshwani, Rachna, Angley, Eleanor, Zacharin, Margaret
Format Journal Article
LanguageEnglish
Published Australia Blackwell Publishing Ltd 01.02.2024
Subjects
Adolescent
Adult
Chorionic Gonadotropin - therapeutic use
Female
Fertility
Follicle Stimulating Hormone
Hormone replacement therapy
Humans
Hypogonadism - drug therapy
Infant
Male
Pediatrics
Pregnancy
Puberty
Recombinant Proteins - therapeutic use
Spermatogenesis
Testosterone - therapeutic use
Virilism
hypogonadotropic hypogonadism
Kallmann syndrome
fertility
pregnancy
gonadotropin
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Summary:Hormone replacement therapy with testosterone for pubertal induction in boys with congenital hypogonadotropic hypogonadism (CHH) achieves virilization but not spermatogenesis. By contrast, human chorionic gonadotropin (hCG) and recombinant follicle stimulating hormone (rFSH) provides both virilization and spermatogenesis. Fertility outcomes of boys treated with recombinant therapy during adolescence have been infrequently described. We report fertility induction and pregnancy outcomes in CHH patients treated with recombinant gonadotropins during puberty. Data of six subjects with CHH (n = 3 Kallmann syndrome & n = 3 Isolated hypogonadotropic hypogonadism) treated with hCG and FSH for pubertal induction were reviewed. Of these, five underwent subsequent fertility induction while one desired fertility at the end of pubertal induction. Partners of all subjects achieved pregnancies using hCG and rFSH, all with full term live births. All infants were clinically normal. This study provides early evidence of proof of concept of use of gonadotropin induction of puberty being beneficial in subsequent fertility outcome.
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ISSN:1034-4810
1440-1754
1440-1754
DOI:10.1111/jpc.16540