Recovery of parathyroid hormone secretion after parathyroid adenomectomy

Using a sensitive two-site immunoradiometric assay which detects only intact human PTH-(1-84), we studied the kinetics of PTH secretion in 19 patients undergoing unilateral neck exploration and removal of a parathyroid adenoma. Preoperative serum PTH values averaged 116 ng/L (normal, 12-65 ng/L). In...

Full description

Saved in:
Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 66; no. 3; p. 495
Main Authors Brasier, A R, Wang, C A, Nussbaum, S R
Format Journal Article
LanguageEnglish
Published United States 01.03.1988
Subjects
Adenoma - secretion
Adenoma - surgery
Adult
Aged
Calcium - blood
Female
Humans
Hypoparathyroidism - complications
Male
Middle Aged
Parathyroid Hormone - secretion
Parathyroid Neoplasms - secretion
Parathyroid Neoplasms - surgery
Phosphates - blood
Postoperative Complications
Radioligand Assay - methods
Online AccessGet more information

Cover

More Information
Summary:Using a sensitive two-site immunoradiometric assay which detects only intact human PTH-(1-84), we studied the kinetics of PTH secretion in 19 patients undergoing unilateral neck exploration and removal of a parathyroid adenoma. Preoperative serum PTH values averaged 116 ng/L (normal, 12-65 ng/L). In 8 patients in whom intraoperative sampling was performed, clearance of PTH-(1-84) was rapid, with virtual disappearance of PTH by 120 min after clamping the vascular pedicle to the adenoma. Analysis of the rate of disappearance of PTH-(1-84) indicated an exponential decay with a half-life of 21 min. Thirteen of 19 patients had serum PTH values less than 1 ng/L within 8 h after parathyroidectomy. Recovery of PTH secretion from the suppressed nonsurgically manipulated parathyroid tissue occurred during the nadir of postoperative hypocalcemia. Serum PTH was greater than 10 ng/L in 16 of 19 patients 30 h after removal of the PTH adenoma. Therefore, the functional recovery of atrophic parathyroid tissue is more rapid than that of other endocrine tissues studied to date.
ISSN:0021-972X
DOI:10.1210/jcem-66-3-495