RGD-decorated solid lipid nanoparticles enhance tumor targeting, penetration and anticancer effect of asiatic acid

Asiatic acid (AA) is a promising anticancer agent, however, its delivery to glioblastoma is a major challenge. This work investigates the beneficial therapeutic efficacy of RGD-conjugated solid lipid nanoparticles (RGD-SLNs) for the selective targeting of AA to gliblastoma.   AA-containing RGD-SLNs...

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Bibliographic Details
Published inNanomedicine (London, England) Vol. 15; no. 16; pp. 1567 - 1583
Main Authors Garanti, Tanem, Alhnan, Mohamed A, Wan, Ka-Wai
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.07.2020
Subjects
Apoptosis
Arg-Gly-Asp
arginine-glycine-aspartic acid
Blood-brain barrier
Brain cancer
Cancer therapies
Cell adhesion & migration
Cell culture
Efficiency
Glioma
Lipids
Medical prognosis
Microscopy
nanomedicine and PEG
Nanoparticles
nanotechnology
Peptides
targeted delivery
United Kingdom > UK
Germany
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Summary:Asiatic acid (AA) is a promising anticancer agent, however, its delivery to glioblastoma is a major challenge. This work investigates the beneficial therapeutic efficacy of RGD-conjugated solid lipid nanoparticles (RGD-SLNs) for the selective targeting of AA to gliblastoma.   AA-containing RGD-SLNs were prepared using two different PEG-linker size. Targetability and efficacy were tested using monolayer cells and spheroid tumor models. RGD-SLNs significantly improved cytotoxicity of AA against U87-MG monolayer cells and enhanced cellular uptake compared with non-RGD-containing SLNs. In spheroid models, AA-containing RGD-SLNs showed superior control in tumor growth, improved cytotoxicity and enhanced spheroid penetration when compared with AA alone or non-RGD-containing SLNs. This study illustrates the potential of AA-loaded RGD-SLNs as efficacious target-specific treatment for glioblastoma.
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ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2020-0035