The reference genome sequence of Saccharomyces cerevisiae: then and now

• Published in: G3 : genes - genomes - genetics Vol. 4; no. 3; pp. 389 - 398
• Main Authors: Engel, Stacia R, Dietrich, Fred S, Fisk, Dianna G, Binkley, Gail, Balakrishnan, Rama, Costanzo, Maria C, Dwight, Selina S, Hitz, Benjamin C, Karra, Kalpana, Nash, Robert S, Weng, Shuai, Wong, Edith D, Lloyd, Paul, Skrzypek, Marek S, Miyasato, Stuart R, Simison, Matt, Cherry, J Michael
• Format: Journal Article
• Language: English
• Published: United States Genetics Society of America 20.03.2014
• Subjects: Chromosome Mapping; Databases, Factual; Genome, Fungal; Internet; Investigations; Open Reading Frames; Saccharomyces cerevisiae - genetics; Sequence Analysis, DNA; User-Computer Interface; reference sequence; genome release; model organism; S288C; Saccharomyces cerevisiae
• ISSN: 2160-1836; 2160-1836
• DOI: 10.1534/g3.113.008995

The genome of the budding yeast Saccharomyces cerevisiae was the first completely sequenced from a eukaryote. It was released in 1996 as the work of a worldwide effort of hundreds of researchers. In the time since, the yeast genome has been intensively studied by geneticists, molecular biologists, and computational scientists all over the world. Maintenance and annotation of the genome sequence have long been provided by the Saccharomyces Genome Database, one of the original model organism databases. To deepen our understanding of the eukaryotic genome, the S. cerevisiae strain S288C reference genome sequence was updated recently in its first major update since 1996. The new version, called "S288C 2010," was determined from a single yeast colony using modern sequencing technologies and serves as the anchor for further innovations in yeast genomic science.