High variability within Candida albicans transcription factor RLM1: Isolates from vulvovaginal infections show a clear bias toward high molecular weight alleles

• Published in: Medical mycology (Oxford) Vol. 56; no. 5; p. 649
• Main Authors: Carvalho-Pereira, Joana, Oliveira, Manoel Marques Evangelista, Costa-Barbosa, Augusto, Vaz, Catarina, Velegraki, Aristea, Zancopé-Oliveira, Rosely Maria, Pais, Célia, Sampaio, Paula
• Format: Journal Article
• Language: English
• Published: England 01.07.2018
• Subjects: Alleles; Brazil; Candida albicans - classification; Candida albicans - genetics; Candida albicans - isolation & purification; Candidiasis - microbiology; Candidiasis, Vulvovaginal - microbiology; DNA, Fungal - genetics; Female; Fungal Proteins - genetics; Gene Frequency; Genetic Association Studies; Genetic Variation; Genotype; Greece; Humans; Microsatellite Repeats; Molecular Weight; Portugal; Transcription Factors - genetics

Previous studies have correlated the severity of recurrent vulvovaginal Candida infections (VVC) and balanitis in patients from China with the presence of some dominant genotypes at the ORF RLM1. Here we tested VVC vs non-VVC isolates from Portugal, Brazil and Greece and, although the same genotypes...