High variability within Candida albicans transcription factor RLM1: Isolates from vulvovaginal infections show a clear bias toward high molecular weight alleles

Previous studies have correlated the severity of recurrent vulvovaginal Candida infections (VVC) and balanitis in patients from China with the presence of some dominant genotypes at the ORF RLM1. Here we tested VVC vs non-VVC isolates from Portugal, Brazil and Greece and, although the same genotypes...

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Bibliographic Details
Published inMedical mycology (Oxford) Vol. 56; no. 5; p. 649
Main Authors Carvalho-Pereira, Joana, Oliveira, Manoel Marques Evangelista, Costa-Barbosa, Augusto, Vaz, Catarina, Velegraki, Aristea, Zancopé-Oliveira, Rosely Maria, Pais, Célia, Sampaio, Paula
Format Journal Article
LanguageEnglish
Published England 01.07.2018
Subjects
Alleles
Brazil
Candida albicans - classification
Candida albicans - genetics
Candida albicans - isolation & purification
Candidiasis - microbiology
Candidiasis, Vulvovaginal - microbiology
DNA, Fungal - genetics
Female
Fungal Proteins - genetics
Gene Frequency
Genetic Association Studies
Genetic Variation
Genotype
Greece
Humans
Microsatellite Repeats
Molecular Weight
Portugal
Transcription Factors - genetics
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Summary:Previous studies have correlated the severity of recurrent vulvovaginal Candida infections (VVC) and balanitis in patients from China with the presence of some dominant genotypes at the ORF RLM1. Here we tested VVC vs non-VVC isolates from Portugal, Brazil and Greece and, although the same genotypes were identified in VVC isolates, they were present in only five out of 150 strains. However, this analysis showed that VVC isolates presented a higher percentage of genotypes with similar high molecular weight alleles, in comparison with strains isolated from other biological sources.
ISSN:1460-2709
DOI:10.1093/mmy/myx079