High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression

The soluble CD14 (sCD14) level was found associated with mortality during the chronic phase of human immunodeficiency virus (HIV) infection. Here we assessed its prognostic value in 138 patients with primary HIV infection. Higher sCD14 levels were associated with death, from myocardial infarction, b...

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Published inThe Journal of infectious diseases Vol. 212; no. 6; pp. 909 - 913
Main Authors Krastinova, Evguenia, Lecuroux, Camille, Leroy, Carole, Seng, Remonie, Cabie, Andre, Rami, Agathe, Venet, Alain, Meyer, Laurence, Goujard, Cecile
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 15.09.2015
Subjects
Adult
Aged
Anti-Retroviral Agents - therapeutic use
Biomarkers - blood
CD4 Lymphocyte Count
Cohort Studies
Disease Progression
HIV Infections - drug therapy
HIV Infections - mortality
HIV Infections - virology
HIV-1
HIV/AIDS
Human immunodeficiency virus 1
Humans
Lipopolysaccharide Receptors - blood
Male
Viral Load
HIV-1
mortality
systemic inflammation
sCD14
immune activation
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Summary:The soluble CD14 (sCD14) level was found associated with mortality during the chronic phase of human immunodeficiency virus (HIV) infection. Here we assessed its prognostic value in 138 patients with primary HIV infection. Higher sCD14 levels were associated with death, from myocardial infarction, but this was based on 3 deaths only. Among 68 untreated patients, those with higher sCD14 levels had more rapid spontaneous CD4 cell decline during the first 18 months following primary infection. This association persisted after adjustment for age, the CD4 cell count, and HIV viral load at diagnosis.
Bibliography:ObjectType-Article-1
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiv145