Cutaneous changes: an initial manifestation of pulmonary Wegener's granulomatosis

Cutaneous vasculitis can occur as an isolated dermatologic disorder or as manifestation of a potentially life-threatening systemic vasculitis such as Wegener's granulomatosis (WG). The aim of the study was to characterize cutaneous lesions in 66 WG patients (30 female, 36 male) and to assess th...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 755; p. 307
Main Authors Zycinska, Katarzyna, Wardyn, Kazimierz, Zielonka, Tadeusz M, Nitsch-Osuch, Aneta, Smolarczyk, Roman
Format Journal Article
LanguageEnglish
Published United States 01.01.2013
Subjects
Aged
Female
Granulomatosis with Polyangiitis - complications
Granulomatosis with Polyangiitis - pathology
Humans
Male
Middle Aged
Skin - pathology
Skin Diseases - etiology
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Summary:Cutaneous vasculitis can occur as an isolated dermatologic disorder or as manifestation of a potentially life-threatening systemic vasculitis such as Wegener's granulomatosis (WG). The aim of the study was to characterize cutaneous lesions in 66 WG patients (30 female, 36 male) and to assess the viability of skin biopsy the diagnosis of WG. Skin involvement was observed in 21 (32%) WG patients; in 14 (21%) patients as an initial manifestation and in other seven during the diagnosis establishment. Cutaneous lesions included palpable purpura(n=10), subcutaneous nodules(=4), hemorrhagic bullae (n=3), ulcers (n=2), pustules (n=1), pyoderma gangrenosum (n =1). The patient with pulmonary WG can present initially with cutaneous symptoms and positive PR3-ANCA serologic test results. Leukocytoclastic vasculitis (LCV) was the predominant histopathologic pattern.
ISSN:0065-2598
DOI:10.1007/978-94-007-4546-9_39