Mouse chromosome 12

• Published in: Mammalian genome Vol. 10; no. 10; p. 953
• Main Authors: D'Eustachio, P, Riblet, R
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.10.1999
• Subjects: Animals; Chromosome Mapping; Chromosomes - genetics; Databases as Topic; Genetic Markers; Mice
• ISSN: 0938-8990; 1432-1777
• DOI: 10.1007/s003359901131

Comprehensive primary genetic data for the mouse are provided by the Mouse Genome Database (MGD) and several more specialized databases accessible via the World-Wide Web. This report is useful as an entry point to allow users to note the genes and markers likely to fall in a physical or genetic sub-region of Chromosome 12, preparatory to a search of MGD and other primary resources to retrieve complete data. The genetic organization of Chromosome 12 (Table 1) is largely unchanged: newly mapped markers (noted with asterisks in Table 1) have been interpolated into the 62-bin map of Chromosome 12 developed previously (26922) without affecting either the length of the map or the placements of previously well-mapped markers. Reliability of marker placement in the genetic map has been indicated on a scale from 1 (most reliable) to 3 (least reliable). These indications should be viewed cautiously. Marker orders determined from patterns of co-segregation within a single cross can be highly reliable, but marker orders determined by interpolation of data from different crosses are often unreliable, even when the individual crosses each yielded reliable orders. Data obtained by following the inheritance of chromosomal rearrangements and translocations cytogenetically in a cross segregating for conventional markers present an extreme form of this difficulty, as crossing over is strongly perturbed in the vicinity of many rearrangements (e.g., 3979). As a result, Robertsonian translocations are assigned to the centromere of the cytogenetic map and bin 0 of the genetic map of Chromosome 12, but with a reliability score of 3, and all other chromosomal rearrangements are classified as syntenic, regardless of the amount or quality of available genetic data concerning the rearrangement.