Renal involvement in sarcoidosis--a report of 6 cases

This report concerns 6 patients with renal involvement in sarcoidosis. Two of the patients had no clinical symptoms at all. In 3 patients, no extrarenal organ manifestation was found. All 6 patients had elevated levels of serum creatinine, 2 were hypercalcemic. Five patients manifested with mild pro...

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Bibliographic Details
Published inClinical nephrology Vol. 57; no. 2; p. 142
Main Authors Brause, M, Magnusson, K, Degenhardt, S, Helmchen, U, Grabensee, B
Format Journal Article
LanguageEnglish
Published Germany 01.02.2002
Subjects
Adult
Aged
Female
Humans
Kidney - pathology
Male
Middle Aged
Nephritis, Interstitial - complications
Nephritis, Interstitial - pathology
Nephrocalcinosis - complications
Nephrocalcinosis - pathology
Sarcoidosis - complications
Sarcoidosis - pathology
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Summary:This report concerns 6 patients with renal involvement in sarcoidosis. Two of the patients had no clinical symptoms at all. In 3 patients, no extrarenal organ manifestation was found. All 6 patients had elevated levels of serum creatinine, 2 were hypercalcemic. Five patients manifested with mild proteinuria, but in none of the cases was a nephritic sediment with erythrocytes found. Kidney biopsies in 5 patients showed epitheloid cell granulomatous interstitial nephritis, and 1 patient presented with nephrocalcinosis. All patients were treated with corticosteroids. The serum creatinine levels decreased significantly in 4 patients (> 50% decrease), and slightly in 2 patients, elevated serum calcium levels were normalized. Thus, even in the absence of other organ manifestations, sarcoidosis can be the cause of renal insufficiency, and it responds well to corticosteroid treatment. These patients demonstrate the importance of kidney biopsy in the unexplained deterioration of renal function.
ISSN:0301-0430
DOI:10.5414/CNP57142