Analysis of personal care products on model skin surfaces using DESI and PADI ambient mass spectrometry

Two ambient ionisation techniques, desorption electrospray ionisation (DESI) and plasma assisted desorption ionisation (PADI), have been used to analyse personal care products (PCPs) on fixed fibroblast cell surfaces. The similarities and differences between the two techniques for this type of analy...

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Bibliographic Details
Published inAnalyst (London) Vol. 136; no. 16; pp. 3274 - 3280
Main Authors SALTER, Tara L, GREEN, Felicia M, FARUQUI, Nilofar, GILMORE, Ian S
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 21.08.2011
Subjects
Analogies
Analytical chemistry
Chemistry
Cosmetics - analysis
Cream
Damage
Desorption
Exact sciences and technology
Fibroblasts
Fibroblasts - chemistry
Fibroblasts - cytology
Humans
Mass spectrometry
Mathematical models
Models, Biological
Skin - chemistry
Spectrometric and optical methods
Spectrometry, Mass, Electrospray Ionization
Plasma
Use
Product
Desorption
Time
Plasma sources
Cell surface
Electrospray
Chemical ionization
Molecules
Reduction
Signal
Sample preparation
Morphology
Parameter
Skin
Limit
Technique
Fibroblast
Mass spectrometry
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Summary:Two ambient ionisation techniques, desorption electrospray ionisation (DESI) and plasma assisted desorption ionisation (PADI), have been used to analyse personal care products (PCPs) on fixed fibroblast cell surfaces. The similarities and differences between the two techniques for this type of analysis have been explored in various ways. Here, we show the results of DESI and PADI analysis of individual PCP ingredients as well as the analysis of these as complex creams on model skin surfaces, with minimal sample preparation. Typically, organosiloxanes and small molecules were detected from the creams. A study of the morphological damage of the fibroblast cells by the two ionisation techniques showed that for a less than 10% reduction in cell number, acquisition times should be limited to 5 s for PADI, which gives good signal levels; with DESI, the morphological damage was negligible. The operating parameters for the plasma source were optimised, and it was also found that the parameters could be modified to vary the relative intensity of different ions in the mass spectrum.
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ISSN:0003-2654
1364-5528
DOI:10.1039/c1an15138j