Recent advances in immunotherapy and its combination therapies for advanced melanoma: a review

The incidence of melanoma is increasing year by year and is highly malignant, with a poor prognosis. Its treatment has always attracted much attention. Among the more clinically applied immunotherapies are immune checkpoint inhibitors, bispecific antibodies, cancer vaccines, adoptive cell transfer t...

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Published inFrontiers in oncology Vol. 14; p. 1400193
Main Authors Xu, Jiamin, Mu, Shukun, Wang, Yun, Yu, Suchun, Wang, Zhongming
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.07.2024
Subjects
combination therapy
immune checkpoint inhibitors
melanoma
Oncology
oncolytic virus
radiotherapy
radiotherapy
combination therapy
melanoma
immune checkpoint inhibitors
oncolytic virus
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Summary:The incidence of melanoma is increasing year by year and is highly malignant, with a poor prognosis. Its treatment has always attracted much attention. Among the more clinically applied immunotherapies are immune checkpoint inhibitors, bispecific antibodies, cancer vaccines, adoptive cell transfer therapy, and oncolytic virotherapy. With the continuous development of technology and trials, in addition to immune monotherapy, combinations of immunotherapy and radiotherapy have shown surprising efficacy. In this article, we review the research progress of immune monotherapy and combination therapy for advanced melanoma, with the aim of providing new ideas for the treatment strategy for advanced melanoma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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María Moreno, Universidad de la República, Uruguay
Reviewed by: Yoshiaki Yura, Osaka University, Japan
Edited by: Selma Ugurel, Essen University Hospital, Germany
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1400193