The role of phosphotyrosine signaling pathway in a parotid gland proliferation and function

Tyrosine phosphorylation and the intracellular signaling processes associated with it have been the focus of intense study due to its importance in the regulation of biological processes as diverse as cell proliferation and cell differentiation. While much of what we now understand has been derived...

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Bibliographic Details
Published inCritical reviews in oral biology and medicine Vol. 6; no. 2; pp. 119 - 131
Main Authors Purushotham, K R, Humphreys-Beher, M G
Format Journal Article
LanguageEnglish
Published United States 01.01.1995
Subjects
Animals
Cell Differentiation
Cell Division
Dentistry
Exocytosis
Humans
Parotid Gland - cytology
Parotid Gland - secretion
Phosphorylation
Phosphotyrosine - physiology
Protein Tyrosine Phosphatases - physiology
Protein-Tyrosine Kinases - physiology
Signal Transduction
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Summary:Tyrosine phosphorylation and the intracellular signaling processes associated with it have been the focus of intense study due to its importance in the regulation of biological processes as diverse as cell proliferation and cell differentiation. While much of what we now understand has been derived from the study of cell lines and tumor cells, the salivary glands provide a model to examine the effects of tyrosine kinases and tyrosine phosphatases in a normal differentiated tissue. This review will focus, therefore, on the role tyrosine kinases and phosphatases play in inducing the transition from stasis to active proliferation and their potential role in mediating secretory function of the salivary glands.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1045-4411
1544-1113
DOI:10.1177/10454411950060020201