Is C-reactive protein useful in the management of children with suspected bacterial meningitis?

C-reactive protein (CRP) was evaluated in both serum and cerebrospinal fluid in 119 patients to determine if either or both measurements were of clinical value in the diagnosis of bacterial meningitis. CSF C-reactive protein is too insensitive (sensitivity = 66%) to be useful, while serum CRP is too...

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Bibliographic Details
Published inAmerican journal of clinical pathology Vol. 81; no. 6; pp. 779 - 782
Main Authors BENJAMIN, D. R, OPHEIM, K. E, BREWER, L
Format Journal Article
LanguageEnglish
Published Chicago, IL American Society of Clinical Pathologists 01.06.1984
Subjects
Adolescent
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
C-Reactive Protein - analysis
C-Reactive Protein - cerebrospinal fluid
Child
Child, Preschool
Human bacterial diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Medical sciences
Meningitis - blood
Meningitis - cerebrospinal fluid
Meningitis - diagnosis
Meningitis, Aseptic - blood
Meningitis, Aseptic - cerebrospinal fluid
Meningitis, Aseptic - diagnosis
Human
Infection
Anti C protein
Nervous system diseases
Treatment
Bacteriosis
Meningitis
Child
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Summary:C-reactive protein (CRP) was evaluated in both serum and cerebrospinal fluid in 119 patients to determine if either or both measurements were of clinical value in the diagnosis of bacterial meningitis. CSF C-reactive protein is too insensitive (sensitivity = 66%) to be useful, while serum CRP is too nonspecific for routine application. Serum CRP may have a role if used selectively in those patients with a low-grade CSF pleocytosis and a negative Gram's stain.
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ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/81.6.779