Strategy for Clinical Setting of Co-transplantation of Mesenchymal Stem Cells and Pancreatic Islets

• Published in: Cell transplantation Vol. 33; p. 9636897241259433
• Main Authors: Mei, Liang, Yuwei, Yang, Weiping, Liang, Zhiran, Xu, Bingzheng, Feng, Jibing, Chen, Hongjun, Gao
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.01.2024; SAGE Publishing
• Subjects: Animals; Coculture Techniques - methods; Diabetes Mellitus, Type 1 - therapy; Humans; Islets of Langerhans - cytology; Islets of Langerhans Transplantation - methods; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Review; mesenchymal stem cell; type 1 diabetes mellitus; pancreatic islet; co-transplantation; co-culture
• ISSN: 0963-6897; 1555-3892; 1555-3892
• DOI: 10.1177/09636897241259433

Islet transplantation may be the most efficient therapeutic technique for patients with type 1 diabetes mellitus (T1DM). However, the clinical application of this method is faced with numerous limitations, including isolated islet apoptosis, recipient rejection, and graft vascular reconstruction. Mesenchymal stem cells (MSCs) possess anti-apoptotic, immunomodulatory, and angiogenic properties. Here, we review recent studies on co-culture and co-transplantation of islets with MSCs. We have summarized the methods of preparation of co-transplantation, especially the merits of co-culture, and the effects of co-transplantation. Accumulating experimental evidence shows that co-culture of islets with MSCs promotes islet survival, enhances islet secretory function, and prevascularizes islets through various pretransplant preparations. This review is expected to provide a reference for exploring the use of MSCs for clinical islet co-transplantation.