Updates in aortic wall pathology

Several studies have investigated the pathogenesis of aortic wall abnormalities such as aortic dissection or aneurysm; however, the comprehensive pathological in situ event involved in the development of the disease is not understood well. The vasa vasorum form a network of capillaries or venules ar...

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Published inSurgery today (Tokyo, Japan) Vol. 52; no. 12; pp. 1671 - 1679
Main Authors Osada, Hiroaki, Minatoya, Kenji
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.12.2022
Subjects
Medicine
Medicine & Public Health
Review Article
Surgery
Surgical Oncology
Vasa vasorum
Medial degeneration
Pathology
Aortic dissection
Intramural hematoma
Aortic aneurysm
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Summary:Several studies have investigated the pathogenesis of aortic wall abnormalities such as aortic dissection or aneurysm; however, the comprehensive pathological in situ event involved in the development of the disease is not understood well. The vasa vasorum form a network of capillaries or venules around the adventitia and outer media, which play an important role in the aortic wall structure and function. Impairment of their function may induce tissue hypoxia, impede the transfer of cellular nutrients, and cause aortic medial degeneration, which is considered the major predisposing factor to this aortic wall pathology. This review updates our understanding of the pathological changes in the aortic media and vasa vasorum of patients with aortic dissection and aortic aneurysm.
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ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-021-02420-4