A trial using early preoperative administration of cefonicid for antimicrobial prophylaxis with hysterectomies

A single dose of cefonicid given 3.5-5.0 hours or 0.5-1.0 hour preoperatively was compared with cefoxitin given as five doses beginning 0.5-1.0 hour preoperatively for prophylaxis of infection in 202 patients undergoing vaginal or abdominal hysterectomy. The administration of cefonicid 3.5-5.0 hours...

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Bibliographic Details
Published inDICP (Cincinnati, Ohio) Vol. 23; no. 9; p. 655
Main Authors Eron, L J, Gordon, S F, Harvey, L K, Sites, J G
Format Journal Article
LanguageEnglish
Published United States 01.09.1989
Subjects
Adolescent
Adult
Cefonicid - adverse effects
Cefonicid - therapeutic use
Female
Humans
Hysterectomy
Middle Aged
Premedication
Randomized Controlled Trials as Topic
Risk Factors
Surgical Wound Infection - prevention & control
Time Factors
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Summary:A single dose of cefonicid given 3.5-5.0 hours or 0.5-1.0 hour preoperatively was compared with cefoxitin given as five doses beginning 0.5-1.0 hour preoperatively for prophylaxis of infection in 202 patients undergoing vaginal or abdominal hysterectomy. The administration of cefonicid 3.5-5.0 hours preoperatively was intended to simulate situations where surgery may be delayed or prolonged. The trial was double-blind, and patients were randomized to one of the three regimens. Operative site infections were noted in 6.2 percent of patients (7/113) who received cefonicid 3.5-5.0 hours preoperatively, in 7.0 percent of patients (3/43) who received cefonicid 0.5-1.0 hour preoperatively, and in 4.3 percent of patients (2/46) who received cefoxitin (p greater than 0.05). Enterococci were isolated most frequently from operative-site infections. When administered 3.5-5.0 hours preoperatively, cefonicid was as effective as more traditional regimens.
ISSN:1042-9611
DOI:10.1177/106002808902300904