Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases: A prospective, blind clinical study

BACKGROUND Traditional esophagogastroduodenoscopy (EGD), an invasive examination method, can cause discomfort and pain in patients. In contrast, magnetically controlled capsule endoscopy (MCE), a noninvasive method, is being applied for the detection of stomach and small intestinal diseases, but its...

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Published inWorld journal of gastroenterology : WJG Vol. 30; no. 9; pp. 1121 - 1131
Main Authors Yang, Yan-Ling, Qin, Huang-Wen, Chen, Zhao-Yu, Fan, Hui-Ning, Yu, Yi, Da, Wei, Zhu, Jin-Shui, Zhang, Jing
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 07.03.2024
Subjects
Capsule Endoscopy - methods
Clinical Trials Study
Endoscopy, Digestive System - methods
Esophageal Diseases - diagnosis
Humans
Prospective Studies
Sensitivity and Specificity
Detachable string magnetically controlled capsule endoscopy
Esophageal diseases
Esophagogastroduodenoscopy
Noninvasive diagnosis
Clinical trial
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Summary:BACKGROUND Traditional esophagogastroduodenoscopy (EGD), an invasive examination method, can cause discomfort and pain in patients. In contrast, magnetically controlled capsule endoscopy (MCE), a noninvasive method, is being applied for the detection of stomach and small intestinal diseases, but its application in treating esophageal diseases is not widespread. AIM To evaluate the safety and efficacy of detachable string MCE (ds-MCE) for the diagnosis of esophageal diseases. METHODS Fifty patients who had been diagnosed with esophageal diseases were prospectively recruited for this clinical study and underwent ds-MCE and conventional EGD. The primary endpoints included the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of ds-MCE for patients with esophageal diseases. The secondary endpoints consisted of visualizing the esophageal and dentate lines, as well as the subjects' tolerance of the procedure. RESULTS Using EGD as the gold standard, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of ds-MCE for esophageal disease detection were 85.71%, 86.21%, 81.82%, 89.29%, and 86%, respectively. ds-MCE was more comfortable and convenient than EGD was, with 80% of patients feeling that ds-MCE examination was very comfortable or comfortable and 50% of patients believing that detachable string v examination was very convenient. CONCLUSION This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD, providing a novel noninvasive method for treating esophageal diseases.
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Supported by the Science and Technology Commission of Shanghai, No. 18DZ1930309.
Corresponding author: Jing Zhang, MD, Associate Chief Physician, Department of Gastroenterology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. jing5522724@vip.163.com
Co-corresponding authors: Jin-Shui Zhu and Jing Zhang.
Author contributions: Zhang J, Zhu JS and Da W conceptualized and designed the research; Da W, Yang YL and Qin HW screened patients and acquired clinical data; Chen ZY and Fan HN collected the clinical data; Yu Y performed Data analysis; Yang YL wrote the paper. All the authors have read and approved the final manuscript. Both Zhang J and Zhu JS have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Zhu JS applied for and obtained the funds for this research project. Zhu JS conceptualized, designed, and supervised the whole process of the project. Zhu JS searched the literature, revised the early version of the manuscript with the focus on the safety of detachable string magnetically controlled capsule endoscopy (ds-MCE) for identifying esophageal diseases. Zhang J was instrumental and responsible for data re-analysis and re-interpretation, figure plotting, comprehensive literature search, preparation and submission of the current version of the manuscript with a new focus on the efficacy of ds-MCE for the diagnosis of esophageal diseases. This collaboration between Zhang J and Zhu JS is crucial for the publication of this manuscript and other manuscripts still in preparation.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v30.i9.1121