Lactate dehydrogenase activity in laryngeal carcinoma and surrounding mucosa

The total lactate dehydrogenase (LDH) activity and LDH isoenzyme pattern were measured in tissue taken from laryngeal cancers and from the laryngeal mucosa both close to and distant from the tumour margin. An increase in the total LDH activity and a cathodic shift in the isoenzyme pattern were found...

Full description

Saved in:
Bibliographic Details
Published inClinical otolaryngology and allied sciences Vol. 9; no. 1; p. 9
Main Authors Gołabek, W, Szyszko, J
Format Journal Article
LanguageEnglish
Published England 01.02.1984
Subjects
Adult
Aged
Carcinoma, Squamous Cell - enzymology
Humans
Isoenzymes
L-Lactate Dehydrogenase - metabolism
Laryngeal Mucosa - enzymology
Laryngeal Neoplasms - enzymology
Larynx - enzymology
Middle Aged
Online AccessGet more information

Cover

More Information
Summary:The total lactate dehydrogenase (LDH) activity and LDH isoenzyme pattern were measured in tissue taken from laryngeal cancers and from the laryngeal mucosa both close to and distant from the tumour margin. An increase in the total LDH activity and a cathodic shift in the isoenzyme pattern were found in tumour tissue compared to the close and distant mucosa. However, significant LDH alterations in the mucosa close to the tumour were shown in comparison to the distant mucosa and to the laryngeal mucosa of controls. Histochemical studies showed the LDH activity to be located in the basal and parabasal layers of the epithelium and in the cancer foci.
ISSN:0307-7772
1365-2273
DOI:10.1111/j.1365-2273.1984.tb01466.x