Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical considerations

Preimplantation genetic testing (PGT) has emerged as a powerful companion to assisted reproduction technologies. The origins and history of PGT are reviewed here, along with descriptions of advances in molecular assays and sampling methods, their capabilities, and their applications in preventing ge...

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Bibliographic Details
Published inMolecular reproduction and development Vol. 91; no. 1; pp. e23727 - n/a
Main Author Latham, Keith E.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.01.2024
Subjects
embryo
Ethics
Genetic disorders
Genetic screening
Genomes
oocyte
preimplantation genetic screening
preimplantation genetic testing
preimplantation genetic testing
embryo
oocyte
preimplantation genetic screening
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Summary:Preimplantation genetic testing (PGT) has emerged as a powerful companion to assisted reproduction technologies. The origins and history of PGT are reviewed here, along with descriptions of advances in molecular assays and sampling methods, their capabilities, and their applications in preventing genetic diseases and enhancing pregnancy outcomes. Additionally, the potential for increasing accuracy and genome coverage is considered, as well as some of the emerging ethical and legislative considerations related to the expanding capabilities of PGT.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.23727