Koebnerizing sclerodermatous graft‐versus‐host disease caused by donor lymphocyte infusion and interferon‐α

• Published in: British journal of dermatology (1951) Vol. 155; no. 3; pp. 621 - 623
• Main Authors: White, J.M.L., Devereux, S., Pagliuca, A., Salisbury, J.R., Du Vivier, A.W.P., Creamer, D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2006; Blackwell
• Subjects: Adult; Antineoplastic Agents - adverse effects; Biological and medical sciences; Dermatology; donor lymphocyte infusion; Drug Eruptions - etiology; Drug Eruptions - pathology; Graft vs Host Disease - chemically induced; Graft vs Host Disease - etiology; Graft vs Host Disease - pathology; Hodgkin Disease - therapy; Humans; Interferon-alpha - adverse effects; interferon‐α; lichen sclerosus; Lymphocyte Transfusion - adverse effects; Male; Medical sciences; Psoriasis. Parapsoriasis. Lichen; Scleroderma, Localized - chemically induced; Scleroderma, Localized - etiology; Scleroderma, Localized - pathology; sclerodermatous graft‐versus‐host disease; Human; Immunopathology; Koebner phenomenon; Skin disease; Dermatology; Alpha interferon; Lichen sclerosus et atrophicus; Graft versus host reaction; donor lymphocyte infusion; lichen sclerosus; Case study; interferon-a; Perfusion; sclerodermatous graft-versus- host disease; Lymphocyte
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1111/j.1365-2133.2006.07404.x

Summary Graft‐versus‐host disease (GvHD) is a common sequel to allogeneic bone marrow transplants, which may be accompanied by desirable graft‐versus‐tumour effects. Sclerodermatous GvHD is a rare subtype that is very difficult to treat. We report the first case of sclerodermatous GvHD as part of the Koebner phenomenon. We propose that donor lymphocyte infusion and interferon‐α were involved in the pathogenesis of this case.