A case of Ki-1 positive anaplastic large cell lymphoma transformed from mycosis fungoides

• Published in: Journal of dermatology Vol. 23; no. 9; p. 606
• Main Authors: Kudo, Y, Katagiri, K, Ise, T, Imamura, Y, Takayasu, S
• Format: Journal Article
• Language: English
• Published: England 01.09.1996
• Subjects: Aged; Biopsy, Needle; Cell Transformation, Neoplastic; Combined Modality Therapy; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Lymphoma, Large-Cell, Anaplastic - etiology; Lymphoma, Large-Cell, Anaplastic - pathology; Lymphoma, Large-Cell, Anaplastic - therapy; Mycosis Fungoides - complications; Mycosis Fungoides - pathology
• ISSN: 0385-2407
• DOI: 10.1111/j.1346-8138.1996.tb02663.x

A case of cutaneous Ki-1 positive anaplastic large cell lymphoma which developed in the plaque stage of mycosis fungoides was described. A 73-year-old woman who had suffered from pruritic scaly eruptions over her entire body for more than two decades was admitted because of an ulcerated tumor measuring 45 x 55 x 15 mm and several satellite tumors on the buttock. All tumorous lesions were resected without recurrence to date. Histochemical study revealed that the tumor consisted of large anaplastic cells which were Ki-1 (CD30)-positive and LCA-negative. Some of the erythematous plaques contained LCA-positive, small-sized atypical lymphocytes. In other plaques which developed two years later, there were large Ki-1-positive atypical cells. In the specimens obtained from the tumor and the plaque, the same pattern of T-cell receptor gene rearrangements was detected. These findings indicate that both Ki-1 positive anaplastic cells in the tumor and atypical lymphoid cells in the plaques were derived from the same T cell clone.