Statin use and the reoperation rates in glaucoma filtration surgery – population‐based cohort study

• Published in: Acta ophthalmologica (Oxford, England) Vol. 100; no. 1; pp. e167 - e173
• Main Authors: Virtanen, Aapo, Haukka, Jari, Harju, Mika, Loukovaara, Sirpa
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2022
• Subjects: Aged; Cataracts; clinical epidemiology; Cohort analysis; cohort study; Eye; Female; Filtering Surgery - methods; Filtration; Finland - epidemiology; Follow-Up Studies; Glaucoma; Glaucoma Drainage Implants; glaucoma filtration surgery; Glaucoma, Open-Angle - drug therapy; Glaucoma, Open-Angle - physiopathology; Glaucoma, Open-Angle - surgery; Health care; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Incidence; Intraocular Pressure - physiology; Male; medication; Middle Aged; Patients; Population studies; Population Surveillance - methods; Population-based studies; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Registries; Reoperation - statistics & numerical data; Retrospective Studies; statin; Statins; Surgery; Time Factors; Finland; glaucoma filtration surgery; medication; cohort study; statin; clinical epidemiology
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.14860

Purpose To examine the association of systemic statin therapy and reoperation rate after glaucoma filtration surgery (GFS). Methods This is a population‐based, historic cohort study of 2705 eyes undergoing GFS in Finland between July 2009 and December 2016. GFSs were identified from national administrative healthcare registers. Baseline sociodemographic and health characteristics were documented. Reoperation rates of GFS subgroups were analysed, with statin users compared to non‐users. The outcomes were modelled using a Poisson regression model adjusted for age, sex, education, statin use, chronic comorbidities, and cataract surgery with incident rate ratios (IRR) as the main outcome measure. Results The cohort contained 2263 subjects with open‐angle glaucoma (OAG), 823 men and 1440 women. Surgery was performed on 2705 eyes. First documented procedures: deep sclerectomy (DS) (n = 1601), trabeculectomy (TRE) (799) and glaucoma drainage device (GDD) implantation (305) respectively. In total, 438 secondary operations were performed during the 7.5‐year (median 2.25 years) follow‐up period. The reoperation rates were 19% after DS, 12% after TRE, and 13% after GDD. Of the surgical procedures, 32% were performed on eyes of patients receiving statin therapy. Statin users showed no difference in reoperation rates (IRR 1.06, CI 0.82–1.37). In subgroups, no difference was observed in the reoperation rates adjusted with statin use after filtration surgery (DS, TRE) (IRR 1.06, CI 0.8–1.40) or GDD implantation (0.57, CI 0.20–1.63). Conclusion Systemic statin therapy among surgically treated OAG patients had no impact on secondary surgery rates following DS, TRE or GDD implantation.