Anti-plakin and Desmoglein Autoantibodies in a Dog with Pemphigus Vulgaris

Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retriever because of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and −...

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Published inVeterinary pathology Vol. 37; no. 5; pp. 496 - 499
Main Authors Olivry, T., Alhaidari, Z., Ghohestani, R. F.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.09.2000
Subjects
Animals
Apoptosis
Autoantibodies - analysis
Cytoskeletal Proteins - immunology
Desmoglein 1
Desmogleins
Desmoplakins
Dog Diseases - immunology
Dogs
Euthanasia - veterinary
Immunoglobulin G - analysis
Keratinocytes - pathology
Male
Membrane Proteins - immunology
Pemphigus - immunology
Pemphigus - veterinary
Protein Precursors - immunology
Autoimmunity
dogs
skin
blistering dermatoses
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Summary:Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retriever because of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and −3) antigens. Necropsy, however, failed to confirm the concurrent existence of hematopoietic or solid neoplasia. The diagnosis of pemphigus vulgaris therefore was proposed. This study illustrates that such a combination of clinicopathologic lesions and plakin/desmoglein-specific autoantibodies is not restricted to canine paraneoplastic pemphigus but can also be detected in another form of suprabasal pemphigus.
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ISSN:0300-9858
1544-2217
DOI:10.1354/vp.37-5-496