Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis

A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-assoc...

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Bibliographic Details
Published inNeurology Vol. 67; no. 1; p. 146
Main Authors Blumenthal, D T, Salzman, K L, Digre, K B, Jensen, R L, Dunson, W A, Dalmau, J
Format Journal Article
LanguageEnglish
Published United States 11.07.2006
Subjects
Aged
Antibodies - blood
Antigens, CD - metabolism
Antigens, Neoplasm - immunology
Brain - metabolism
Brain - pathology
Encephalitis - immunology
Encephalitis - pathology
Encephalitis, Herpes Simplex - immunology
Encephalitis, Herpes Simplex - pathology
Follow-Up Studies
Humans
Magnetic Resonance Imaging - methods
Male
Nerve Tissue Proteins - immunology
Poly(A)-Binding Proteins - metabolism
T-Cell Intracellular Antigen-1
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Summary:A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-associated protein TIA-1 and the membranolytic protein granzyme-B. Although recovery was thought to be unlikely, treatment of the PNE with corticosteroids and resection of the associated lung cancer resulted in dramatic improvement for 21 months.
ISSN:1526-632X
DOI:10.1212/01.wnl.0000223647.83708.20