In vivo Fate of Targeted Drug Delivery Carriers

This review aimed to systematically investigate the intracellular and subcellular fate of various types of targeting carriers. Upon entering the body via intravenous injection or other routes, a targeting carrier that can deliver therapeutic agents initiates their journey. If administered intravenou...

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Bibliographic Details
Published inInternational journal of nanomedicine Vol. 19; pp. 6895 - 6929
Main Authors Zhao, Fan, Wang, Jitong, Zhang, Yu, Hu, Jinru, Li, Chenyang, Liu, Shuainan, Li, Ruixiang, Du, Ruofei
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2024
Dove Medical Press
Subjects
Animals
drug carriers
Drug Carriers - chemistry
Drug Carriers - pharmacokinetics
Drug delivery systems
Drug Delivery Systems - methods
Drug Liberation
Drugs
Health aspects
Humans
in vivo fate
Medical research
Medicine, Experimental
Metronidazole
Nanoparticles - chemistry
subcellular fate
targeted delivery
Vehicles
China
drug carriers
subcellular fate
targeted delivery
in vivo fate
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Summary:This review aimed to systematically investigate the intracellular and subcellular fate of various types of targeting carriers. Upon entering the body via intravenous injection or other routes, a targeting carrier that can deliver therapeutic agents initiates their journey. If administered intravenously, the carrier initially faces challenges presented by the blood circulation before reaching specific tissues and interacting with cells within the tissue. At the subcellular level, the car2rier undergoes processes, such as drug release, degradation, and metabolism, through specific pathways. While studies on the fate of 13 types of carriers have been relatively conclusive, these studies are incomplete and lack a comprehensive analysis. Furthermore, there are still carriers whose fate remains unclear, underscoring the need for continuous research. This study highlights the importance of comprehending the in vivo and intracellular fate of targeting carriers and provides valuable insights into the operational mechanisms of different carriers within the body. By doing so, researchers can effectively select appropriate carriers and enhance the successful clinical translation of new formulations.
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ISSN:1178-2013
1178-2013
DOI:10.2147/IJN.S465959