Cholesterol's Function and Origin in the Alzheimer's Disease Brain

Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuroinflammation and altered lipids in the brain. Cholesterol is a key component of inflammatory lipids. However, the role of cholesterol in AD, specifically in sporadic or late-onset AD, has remained poorly understood du...

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Bibliographic Details
Published inJournal of Alzheimer's disease
Main Author Hansen, Scott B
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2023
Subjects
blood-brain barrier
apoE
cholesterol
lipids
Alzheimer’s disease
neuroinflammation
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Summary:Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuroinflammation and altered lipids in the brain. Cholesterol is a key component of inflammatory lipids. However, the role of cholesterol in AD, specifically in sporadic or late-onset AD, has remained poorly understood due to the belief that most brain cholesterol is separate from circulating blood cholesterol. A new theory suggests that the permeation of circulating cholesterol into the brain is a causal event critical for the onset of AD. As research in this area continues, new hypotheses and insights into AD are expected to emerge.
ISSN:1875-8908
DOI:10.3233/JAD-230538