The role of α-satellite DNA and heterochromatin polymorphism in leukemia patients and illicit drug addicts

Heterochromatin is considered to play a role in protecting the genome against mutagens. Changes in the quantity and proportion of different types of satellite DNA could increase genetic susceptibility in individuals with heterochromatic variations; they cause chromosome instability and predispose pa...

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Published inGenetics and molecular research Vol. 10; no. 4; pp. 3999 - 4005
Main Authors Movafagh, A, Mortazavi-Tabatabaei, S A, Kolahi, A A
Format Journal Article
LanguageEnglish
Published Brazil 25.11.2011
Subjects
Adolescent
Adult
Chromosomes, Human - genetics
DNA, Satellite - chemistry
Drug Users
Female
Heterochromatin - metabolism
Humans
Leukemia - genetics
Male
Middle Aged
Polymorphism, Genetic
Street Drugs - adverse effects
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Summary:Heterochromatin is considered to play a role in protecting the genome against mutagens. Changes in the quantity and proportion of different types of satellite DNA could increase genetic susceptibility in individuals with heterochromatic variations; they cause chromosome instability and predispose patients to malignancies. We evaluated the heterochromatin associated with chromosomes in 50 leukemia patients, 93 drug addicts and 93 healthy controls from Tehran, Iran. Barium hydroxide saline Giemsa staining was used to examine heterochromatin polymorphism of chromosomes 1, 9 and 16 in lymphocyte cultures. There were significant differences in this polymorphism in lymphocytes from drug addicts and leukemia patients compared to healthy controls. These polymorphisms could serve as markers for the detection and characterization of chromosome damage in leukemia patients and drug addicts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1676-5680
1676-5680
DOI:10.4238/2001.November.25.3