Lipid Droplet—a New Target in Ischemic Heart Disease

• Published in: Journal of cardiovascular translational research Vol. 15; no. 4; pp. 730 - 739
• Main Authors: Guo, Xiaoying, Shi, Qi, Zhang, Wanqin, Qi, Zhongwen, Lv, Hao, Man, Fujing, Xie, Yingyu, Zhu, Yaping, Zhang, Junping
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2022
• Subjects: Biomedical Engineering and Bioengineering; Biomedicine; Cardiology; Human Genetics; Medicine; Medicine & Public Health; Review; Mitochondrial; Lipid droplets; Endoplasmic reticulum; Myocardial remodeling; Lysosome; Atherosclerosis
• ISSN: 1937-5387; 1937-5395
• DOI: 10.1007/s12265-021-10204-x

Lipid droplet (LD) is a kind of subcellular organelle, which originates from the endoplasmic reticulum (ER). LDs can move flexibly between other organelles and store energy in the cells. In recent years, LDs and lipid droplet–associated proteins have attracted added attention at home and abroad, especially in cardiovascular diseases. Cardiovascular diseases, especially ischemic heart disease (IHD), have always been the focus of attention because of their high morbidity and mortality. Atherosclerosis and myocardial remodeling are two important pathologic processes of IHD, and LDs and other organelles are involved in the development of the disease. The interaction between LDs and ER is involved in the formation of foam cells in atherosclerosis. And LDs, mitochondria, and lysosomes also affect the remodeling of cardiomyocytes by affecting ROS production and regulating PI3K/AKT pathways. In this article, we will review the role of LDs in IHD. Graphical abstract