Appraisal of anti-inflammatory and immunomodulatory potential of ramipril against Freund’s adjuvant-provoked arthritic rat model

• Published in: Inflammopharmacology Vol. 31; no. 6; pp. 3115 - 3125
• Main Authors: Qasim, Sumera, Khan, Yusra Habib, Uttra, Ambreen Malik, Alotaibi, Nasser Hadal, Alanazi, Abdullah Salah, Alzarea, Abdulaziz I., Alatawi, Ahmed D., Mallhi, Tauqeer Hussain
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2023
• Subjects: Allergology; Biomedical and Life Sciences; Biomedicine; Dermatology; Gastroenterology; Immunology; Original Article; Pharmacology/Toxicology; Rheumatology; Pro-inflammatory cytokines; Ramipril; Arthritis; Anti-inflammatory cytokines; CFA
• ISSN: 0925-4692; 1568-5608
• DOI: 10.1007/s10787-023-01306-w

Because of evident role of renin–angiotensin system in the etiology of rheumatoid arthritis, the current study’s objective was to assess the anti-arthritic efficacy of ramipril through CFA-instigated arthritic model. The drug has been shown to have anti-inflammatory potential. CFA-instigated arthritic model assessed the anti-arthritic efficacy of ramipril by estimating different parameters, including paw volume, arthritic index scoring, haematological and biochemical attributes, histological and radiographic analyses, and various cytokines level. Ramipril significantly ( p < 0.001) reduced paw volume and the arthritic index especially at the dose of 4mg/kg. The biochemical and haematological changes were likewise restored to normal by ramipril administration with an increase in anti-inflammatory cytokines while reducing pro-inflammatory cytokines level. Ramipril’s ability to prevent arthritis by preserving the normal architecture of arthritis-induced joints is further supported by radiographic and histological investigation. The study’s findings demonstrated ramipril’s considerable anti-arthritic activity. To identify the precise mechanism of action, however, thorough mechanistic studies are still needed.