Post-irradiation treatment with OK432 can prevent radiation-induced bone marrow death

The radioprotective effect of OK432, a Streptococcus haemolyticus preparation, on bone marrow death was examined in mice. The LD50 value was increased from 7.55 Gy in controls to 8.45 Gy in mice treated once with OK432 immediately after irradiation. Multiple administrations of the agent further elev...

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Bibliographic Details
Published inInternational journal of radiation biology Vol. 59; no. 3; p. 711
Main Authors Kurishita, A, Katoh, H, Uehara, Y, Uchida, A, Mizutani, Y, Ono, T, Hirose, S, Okada, S
Format Journal Article
LanguageEnglish
Published England 1991
Subjects
Animals
Bone Marrow - drug effects
Bone Marrow - radiation effects
Dose-Response Relationship, Radiation
Injections, Intraperitoneal
Mice
Picibanil - administration & dosage
Picibanil - therapeutic use
Radiation Injuries, Experimental - mortality
Radiation Injuries, Experimental - prevention & control
Radiation-Protective Agents - administration & dosage
Radiation-Protective Agents - therapeutic use
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Summary:The radioprotective effect of OK432, a Streptococcus haemolyticus preparation, on bone marrow death was examined in mice. The LD50 value was increased from 7.55 Gy in controls to 8.45 Gy in mice treated once with OK432 immediately after irradiation. Multiple administrations of the agent further elevated the LD50 value to 9.56 Gy. The radioprotective effect was also apparent when multiple treatments were commenced as late as 72 h after irradiation.
ISSN:0955-3002
1362-3095
DOI:10.1080/09553009114550621