Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH2

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 13; no. 16; pp. 2647 - 2650
Main Authors KOIKOV, L. N, EBETINO, F. H, SOLINSKY, M. G, CROSS-DOERSEN, D, KNITTEL, J. J
Format Journal Article
LanguageEnglish
Published Oxford Elsevier 18.08.2003
Subjects
Biological and medical sciences
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Agonist
D stereoisomer
Peptides
Structure activity relation
Tetrapeptide
Peptidergic receptor
Binding site
Hydrophobicity
Chemical synthesis
In vitro
MC1 melanocortin receptor
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ISSN:0960-894X
1464-3405
DOI:10.1016/s0960-894x(03)00552-3