Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Asymmetric catalytic multicomponent cascade reactions have become indispensable tools for enantioselective construction of spirooxindoles. In recent years, a number of successful strategies have been developed for the synthesis of enantioenriched spirooxindoles in high yield with excellent stereo- a...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 8; no. 15; pp. 4315 - 4348
Main Authors Wang, Yongchao, Cobo, Angel A, Franz, Annaliese K
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 07.08.2021
Subjects
Amines
Asymmetry
Cascade chemical reactions
Chemical synthesis
Enantiomers
Organic chemistry
Phosphoric acid
Regioselectivity
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Summary:Asymmetric catalytic multicomponent cascade reactions have become indispensable tools for enantioselective construction of spirooxindoles. In recent years, a number of successful strategies have been developed for the synthesis of enantioenriched spirooxindoles in high yield with excellent stereo- and regioselectivity. This review summarizes the recent advances on enantioselective construction of spirooxindoles including spiro[N-heterocycle-oxindoles], spiro[cycloalkane-oxindoles] and spiro[O-heterocycle-oxindoles] catalyzed by chiral phosphoric acids, amines, and bifunctional thiourea/squaramides.
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ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo00220a