Superoxide radicals play important roles in the pathogenesis of spinal cord injury

To investigated a possible role of superoxide dismutase (SOD) in the pathogenesis of spinal cord injury (SCI), the change in the circulatory status in an experimental SCI model of rats was examined. The blood pressure (BP) of the SCI group decreased markedly by compression or head-up-tilt (60 degree...

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Bibliographic Details
Published inParaplegia Vol. 33; no. 8; p. 450
Main Authors Taoka, Y, Naruo, M, Koyanagi, E, Urakado, M, Inoue, M
Format Journal Article
LanguageEnglish
Published England 01.08.1995
Subjects
Acetylcholine - pharmacology
Animals
Arteries - drug effects
Blood Pressure - drug effects
Head-Down Tilt
Male
Pressure
Rats
Rats, Wistar
Spinal Cord Injuries - etiology
Spinal Cord Injuries - mortality
Superoxide Dismutase - pharmacology
Superoxides - metabolism
Survival Analysis
Vascular Resistance
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Summary:To investigated a possible role of superoxide dismutase (SOD) in the pathogenesis of spinal cord injury (SCI), the change in the circulatory status in an experimental SCI model of rats was examined. The blood pressure (BP) of the SCI group decreased markedly by compression or head-up-tilt (60 degrees). The extent of the BP decrease was diminished by the administration of along acting SOD (SM-SOD) prior to injury. Compression, tilting and the administration of SM-SOD increased the sensitivity of resistant arteries to acetylcholine. SM-SOD treated rats had a significantly lower mortality than was found in untreated rats. These findings indicate that superoxide radicals may contribute to the pathogenesis of spinal cord injury and orthostatic hypotension caused by SCI.
ISSN:0031-1758
DOI:10.1038/sc.1995.98