Sex Differences in Cardiac Transplantation

Purpose of Review The goal of this review was to summarize contemporary evidence surrounding sex differences in heart transplantation (HT). Recent Findings Women have steadily comprised approximately 25% of waitlist candidates and HT recipients. This disparity is likely multifactorial with possible...

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Bibliographic Details
Published inCurrent atherosclerosis reports Vol. 25; no. 12; pp. 995 - 1001
Main Authors Chung, Alice, Hartman, Heidi, DeFilippis, Ersilia M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2023
Subjects
Angiology
Cardiology
Female
Heart Failure - surgery
Heart Transplantation
Humans
Male
Medicine
Medicine & Public Health
Review
Sex Characteristics
Tissue Donors
Topical Collection on Women and Ischemic Heart Disease
Waiting Lists
Sex differences
Disparity
Allosensitization
Heart transplantation
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Summary:Purpose of Review The goal of this review was to summarize contemporary evidence surrounding sex differences in heart transplantation (HT). Recent Findings Women have steadily comprised approximately 25% of waitlist candidates and HT recipients. This disparity is likely multifactorial with possible explanations including barriers in referral to advanced heart failure providers, implicit bias, and concerns surrounding sensitization. Women continue to experience higher waitlist mortality at the highest priority tiers. After HT, there are differences in post-transplant complications and outcomes. Future areas of study should include sex differences in noninvasive surveillance, renal outcomes after transplantation, and patient-reported outcomes. Summary There are important sex-specific considerations that impact candidate selection, donor matching, waitlist and post-transplant outcomes. Concerted efforts are needed to improve referral patterns to ensure transplantation is allocated equally.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1523-3804
1534-6242
DOI:10.1007/s11883-023-01169-0