Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. Recent studies have shown that curcumin (CUR) has neuroprotective effects in PD experimental models. However, its efficacy is limited due to low water solubility, bioavailability, and access to the central n...

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Published inNeurotoxicity research Vol. 39; no. 3; pp. 787 - 799
Main Authors Ramires Júnior, Osmar Vieira, Alves, Barbara da Silva, Barros, Paula Alice Bezerra, Rodrigues, Jamile Lima, Ferreira, Shana Pires, Monteiro, Linda Karolynne Seregni, Araújo, Gabriela de Moraes Soares, Fernandes, Sara Silva, Vaz, Gustavo Richter, Dora, Cristiana Lima, Hort, Mariana Appel
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2021
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Neurobiology
Neurochemistry
Neurology
Neurosciences
Original Article
Pharmacology/Toxicology
Nanoparticles
Oxidative stress
Curcumin
Motor impairment
Parkinson’s disease
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Summary:Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. Recent studies have shown that curcumin (CUR) has neuroprotective effects in PD experimental models. However, its efficacy is limited due to low water solubility, bioavailability, and access to the central nervous system. In this study, we compared the effects of new curcumin-loaded nanoemulsions (NC) and free CUR in an experimental model of PD. Adult Swiss mice received NC or CUR (25 and 50 mg/kg) or vehicle orally for 30 days. Starting on the eighth day, they were administered rotenone (1 mg/kg) intraperitoneally until the 30th day. At the end of the treatment, motor assessment was evaluated by open field, pole test, and beam walking tests. Oxidative stress markers and mitochondrial complex I activity were measured in the brain tissue. Both NC and CUR treatment significantly improved motor impairment, reduced lipoperoxidation, modified antioxidant defenses, and prevented inhibition of complex I. However, NC was more effective in preventing motor impairment and inhibition of complex I when compared to CUR in the free form. In conclusion, our results suggest that NC effectively enhances the neuroprotective potential of CUR and is a promising nanomedical application for PD.
ISSN:1029-8428
1476-3524
DOI:10.1007/s12640-021-00362-w