Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention

Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adu...

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Published inThe Journal of nutrition, health & aging Vol. 28; no. 7; p. 100289
Main Authors Galarregui, Cristina, Navas-Carretero, Santiago, Zulet, M. Angeles, González-Navarro, Carlos J., Martínez, J. Alfredo, de Cuevillas, Begoña, Marcos-Pasero, Helena, Aguilar-Aguilar, Elena, Reglero, Guillermo, Ramirez de Molina, Ana, Chausa, Paloma, Iniesta, Jose M., Hernando, M. Elena, Gómez, Enrique J., Garcia-Rudolph, Alejandro, García-Molina, Alberto, Loria-Kohen, Viviana, Abete, Itziar
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.07.2024
Elsevier
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Summary:Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity. 127 men and women aged between 50 and 80 years with overweight/obesity participated in the study—between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN—and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months. Both strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (−4.3 kg; p < 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality. These results support the benefit of precision nutrition approaches for promoting healthy aging and emotional well-being, enhancing the quality of life in aging populations, during the COVID-19 pandemic.
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ISSN:1279-7707
1760-4788
1760-4788
DOI:10.1016/j.jnha.2024.100289