In Silico Study of the Ion Channel Formed by Tolaasin I Produced by Pseudomonas tolaasii

• Published in: Journal of microbiology and biotechnology Vol. 21; no. 10; pp. 1097 - 1100
• Main Authors: Jo, G.H., Konkuk University, Seoul, Republic of Korea, Hwang, D.S., Konkuk University, Seoul, Republic of Korea, Lee, S.H., Konkuk University, Seoul, Republic of Korea, Woo, Y.K., Konkuk University, Seoul, Republic of Korea, Hyun, J.Y., Konkuk University, Seoul, Republic of Korea, Yong, Y.J., Konkuk University, Seoul, Republic of Korea, Kang, K.R., Konkuk University, Seoul, Republic of Korea, Kim, D.W., National Institute of Animal Science, RDA, Cheonan, Republic of Korea, Lim, Y.H., Konkuk University, Seoul, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Seoul Korean Society for Applied Microbiology 01.10.2011; 한국미생물·생명공학회
• Subjects: Amino Acid Sequence; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Toxins - chemistry; Bacterial Toxins - genetics; Bacterial Toxins - metabolism; Biological and medical sciences; Biotechnology; BLOTCHES; CERCOSPORIOSE; Depsipeptides - chemistry; Depsipeptides - genetics; Depsipeptides - metabolism; Fundamental and applied biological sciences. Psychology; Ion Channels - chemistry; Ion Channels - genetics; Ion Channels - metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Pseudomonas - chemistry; Pseudomonas - genetics; Pseudomonas - metabolism; Pseudomonas tolaasii; Tolaasin ion channel; 생물학; Pseudomonadales; Tolaasin ion channel; Bacteria; Pseudomonadaceae; Ionic channel; Pseudomonas tolaasii; Computer aided analysis
• ISSN: 1017-7825; 1738-8872
• DOI: 10.4014/jmb.1103.03026

A toxin produced by Pseudomonas tolaasii, tolaasin, causes brown blotch disease in mushrooms. Tolaasin forms pores on the cellular membrane and destroys cell structure. Inhibiting the ability of tolaasin to form ion channels may be an effective method to protect against attack by tolaasin. However, it is first necessary to elucidate the three-dimensional structure of the ion channels formed by tolaasin. In this study, the structure of the tolaasin ion channel was determined in silico based on data obtained from nuclear magnetic resonance experiments.