The Role of TGF-ß1 in Osteoarthritis of the Temporomandibular Joint in Two Genetic Mouse Models

• Published in: Archives of oral biology Vol. 67; pp. 68 - 73
• Main Authors: Long, E, Motwani, R, Reece, D, Pettit, N, Hepworth, J, Wong, P, Reynolds, P, Seegmiller, R
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2016
• Subjects: Advanced Basic Science; Animals; Biomarkers - metabolism; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Chondrocytes - metabolism; Chondrodysplasia (cho); Dentistry; Disease Models, Animal; Disease Progression; Disproportionate micromelia (Dmm); Genotype; High-Temperature Requirement A Serine Peptidase 1; Mice; Mutation; Osteoarthritis (OA); Osteoarthritis - genetics; Osteoarthritis - metabolism; Osteoarthritis - pathology; Osteochondrodysplasias - metabolism; Osteochondrodysplasias - pathology; Proteoglycans - genetics; Proteoglycans - metabolism; Serine Endopeptidases - biosynthesis; Serine Endopeptidases - metabolism; Smad2; Smad2 Protein - biosynthesis; Smad2 Protein - metabolism; Temporomandibular joint (TMJ); Temporomandibular Joint - metabolism; Temporomandibular Joint - pathology; Temporomandibular Joint Disorders - metabolism; Temporomandibular Joint Disorders - pathology; Tgf-ß1; Transforming Growth Factor beta1 - biosynthesis; Transforming Growth Factor beta1 - metabolism; Smad2; Disproportionate micromelia ( Dmm); chondrodysplasia ( cho); osteoarthritis (OA); Tgf-ß1; temporomandibular joint (TMJ); Chondrodysplasia (cho); Osteoarthritis (OA); Temporomandibular joint (TMJ); Disproportionate micromelia (Dmm)
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2016.03.004

Highlights • The pathogenesis of Temporomandibular Joint (TMJ) Osteoarthritis (OA) is molecular. • TGF-ß1 plays a role in the molecular signaling pathway leading to TMJ OA. • TGF-ß1 is accompanied by Smad2 and Htra1