Beyond Skin Deep: Phospholipid-Based Nanovesicles as Game-Changers in Transdermal Drug Delivery

Transdermal administration techniques have gained popularity due to their advantages over oral and parenteral methods. Noninvasive, self-administered delivery devices improve patient compliance and control drug release. Transdermal delivery devices struggle with the skin's barrier function. Mol...

Full description

Saved in:
Bibliographic Details
Published inAAPS PharmSciTech Vol. 25; no. 6; p. 184
Main Authors Akl, Mohamed A., Eldeen, Muhammad Alaa, Kassem, Abdulsalam M.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 13.08.2024
Subjects
Administration, Cutaneous
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Carriers - chemistry
Drug Delivery Systems - methods
Humans
Liposomes - chemistry
Nanoparticles - chemistry
Pharmacology/Toxicology
Pharmacy
Phospholipids - chemistry
Review Article
Skin - metabolism
Skin Absorption - drug effects
Skin Absorption - physiology
ethanolic liposome
phospholipid based vesicles
elastic-liposome
transdermal drug delivery
ultra-deformable vesicle
invasomes
Online AccessGet full text

Cover

More Information
Summary:Transdermal administration techniques have gained popularity due to their advantages over oral and parenteral methods. Noninvasive, self-administered delivery devices improve patient compliance and control drug release. Transdermal delivery devices struggle with the skin's barrier function. Molecules over 500 Dalton (Da) and ionized compounds don't permeate through the skin. Drug encapsulation in phospholipid-based vesicular systems is the most effective skin delivery technique. Vesicular carriers include bi-layered liposomes, ultra-deformable liposomes, ethanolic liposomes, transethosomes, and invasomes. These technologies enhance skin drug permeation by increasing formula solubilization, partitioning into the skin, and fluidizing the lipid barrier. Phospholipid-based delivery systems are safe and efficient, making them a promising pharmaceutical and cosmeceutical drug delivery technique. Still, making delivery systems requires knowledge about the physicochemical properties of the drug and carrier, manufacturing and process variables, skin delivery mechanisms, technological advances, constraints, and regulatory requirements. Consequently, this review covers recent research achievements addressing the mentioned concerns.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-024-02896-6