Proneness to psychological distress and risk of Alzheimer disease in a biracial community

Persons without dementia residing in a biracial community completed a brief scale of proneness to psychological distress, and 1,064 were subsequently examined for incident Alzheimer disease (AD) 3 to 6 years later. In analyses controlling for selected demographic and clinical variables, persons pron...

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Bibliographic Details
Published inNeurology Vol. 64; no. 2; p. 380
Main Authors Wilson, R S, Barnes, L L, Bennett, D A, Li, Y, Bienias, J L, Mendes de Leon, C F, Evans, D A
Format Journal Article
LanguageEnglish
Published United States 25.01.2005
Subjects
African Americans - psychology
Aged
Alzheimer Disease - epidemiology
Chicago - epidemiology
Cohort Studies
Disease Susceptibility
European Continental Ancestry Group - psychology
Female
Humans
Incidence
Male
Risk
Sampling Studies
Stress, Psychological - epidemiology
Chicago
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Summary:Persons without dementia residing in a biracial community completed a brief scale of proneness to psychological distress, and 1,064 were subsequently examined for incident Alzheimer disease (AD) 3 to 6 years later. In analyses controlling for selected demographic and clinical variables, persons prone to distress were 2.4 times more likely to develop AD than persons not distress prone. This effect was substantially stronger in white persons compared to African Americans.
ISSN:1526-632X
DOI:10.1212/01.WNL.0000149525.53525.E7