Mesenchymal stem cell therapy for COVID-19 infection

COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and caused millions of deaths in a short time. Many preclinical and clinical studies were performed to discover the most efficient therapy to reduce the mortality of COVID-19 patients. Among various approaches for preventin...

Full description

Saved in:
Bibliographic Details
Published inInflammopharmacology Vol. 32; no. 1; pp. 319 - 334
Main Authors Alavi-Dana, Seyyed Mohammad Matin, Gholami, Yazdan, Meghdadi, Mohammadreza, Fadaei, Mohammad Saleh, Askari, Vahid Reza
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.02.2024
Subjects
Allergology
Biomedical and Life Sciences
Biomedicine
China
COVID-19 - therapy
Cytokine Release Syndrome
Dermatology
Gastroenterology
Humans
Immunology
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Pharmacology/Toxicology
Review
Rheumatology
China
COVID-19
Infection
Inflammation
Fibrosis
Cytokine
Mesenchymal stem cells
Online AccessGet full text

Cover

More Information
Summary:COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and caused millions of deaths in a short time. Many preclinical and clinical studies were performed to discover the most efficient therapy to reduce the mortality of COVID-19 patients. Among various approaches for preventing and treating COVID-19, mesenchymal stem cell (MSC) therapy can be regarded as a novel and efficient treatment for managing COVID-19 patients. In this review, we explain the pathogenesis of COVID-19 infection in humans and discuss the role of MSCs in suppressing the inflammation and cytokine storm produced by COVID-19. Then, we reviewed the clinical trial and systematic review studies that investigated the safety and efficacy of MSC therapy in the treatment of COVID-19 infection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-023-01394-8