Dose-related suppression of REM sleep and PGO waves by the serotonin-1 agonist eltoprazine

Parental administration of the serotonin-1 agonist eltoprazine (0.0625 to 4.0 mg/kg [0.0002 to 0.016 mmol/kg]) in freely moving cats produced significant suppression of electrophysiologic rapid eye movement (REM) sleep signs, ponto-geniculo-occipital (PGO) activity, and REM sleep behavior. The virtu...

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Published inNeuropsychopharmacology (New York, N.Y.) Vol. 8; no. 1; pp. 7 - 13
Main Authors QUATTROCHI, J. J, MAMELAK, A. N, BINDER, D, WILLIAMS, J, HOBSON, J. A
Format Journal Article
LanguageEnglish
Published New York, NY Nature Publishing 1993
Subjects
Animals
Biological and medical sciences
Brain - drug effects
Brain - physiology
Cats
Dose-Response Relationship, Drug
Electrodes, Implanted
Electroencephalography - drug effects
Electroencephalography - methods
Electromyography - drug effects
Male
Medical sciences
Miscellaneous
Motor Activity - drug effects
Multivariate Analysis
Neuropharmacology
Pharmacology. Drug treatments
Piperazines - pharmacology
Serotonin Receptor Agonists - pharmacology
Sleep, REM - drug effects
Fissipedia
Carnivora
Sleep stage
Intraperitoneal administration
Psychotropic
Electrophysiology
Serotonin agonist
Rapid eye movement sleep
Vertebrata
Mammalia
Animal
Pontogeniculooccipital spike
Cat
Mechanism of action
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Summary:Parental administration of the serotonin-1 agonist eltoprazine (0.0625 to 4.0 mg/kg [0.0002 to 0.016 mmol/kg]) in freely moving cats produced significant suppression of electrophysiologic rapid eye movement (REM) sleep signs, ponto-geniculo-occipital (PGO) activity, and REM sleep behavior. The virtual total suppression of REM sleep (0.4%, 4.0 mg/kg) and PGO wave activity (2 to 4 mg/kg) in exchange for increasing amounts of non-REM (NREM) slow-wave sleep was a dose-dependent function of the amount of eltoprazine administered. Wakefulness was unaffected by eltoprazine regardless of dose. Concurrent with this dose-dependent suppression of REM was a dose-dependent increase in electroencephalographic synchrony and mean electromyographic amplitude. Since eltoprazine was found to shift the balance between REM and NREM sleep but did not change the balance between sleep and waking, it is a potentially useful tool for the investigation of serotonergic-cholinergic interaction.
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ISSN:0893-133X
1740-634X
DOI:10.1038/npp.1993.2