Interferon beta-1b treatment does not induce autoantibodies

• Published in: Neurology Vol. 64; no. 6; p. 996
• Main Authors: Polman, C H, Kappos, L, Dahlke, F, Graf, R, Beckmann, K, Bogumil, T, Pozzilli, C, Thompson, A J
• Format: Journal Article
• Language: English
• Published: United States 22.03.2005
• Subjects: Autoantibodies - blood; Autoantibodies - drug effects; Autoantibodies - immunology; Biomarkers; Chemical and Drug Induced Liver Injury; Cohort Studies; Double-Blind Method; Female; Humans; Interferon beta-1b; Interferon-beta - adverse effects; Interferon-beta - immunology; Liver - drug effects; Liver - immunology; Liver - physiopathology; Liver Diseases - blood; Liver Diseases - immunology; Male; Mitochondria - immunology; Multiple Sclerosis - chemically induced; Multiple Sclerosis - drug therapy; Multiple Sclerosis - immunology; Placebo Effect; Sex Distribution; Thyroglobulin - immunology; Thyroid Diseases - blood; Thyroid Diseases - chemically induced; Thyroid Diseases - immunology; Thyroid Gland - drug effects; Thyroid Gland - immunology; Thyroid Gland - physiopathology; Treatment Outcome
• ISSN: 1526-632X
• DOI: 10.1212/01.WNL.0000154522.86947.86

There is little information regarding the potential of interferon beta (IFNbeta) to induce or exacerbate autoimmune disease. Existing data from uncontrolled studies are contradictory and do not differentiate between autoimmune dysfunction, which is frequent in patients with multiple sclerosis (MS), and untoward drug effects. To evaluate the impact of IFNbeta on hepatic, thyroid, and other markers of autoimmunity using data from the European placebo-controlled double-blind, multicenter study of IFNbeta-1b in patients with secondary progressive MS (SPMS). Serum samples obtained at baseline and at 6-month intervals for 24 months were analyzed for the following autoantibodies (AAbs): antinuclear (ANA), antimitochondrial (AMA), smooth muscle (SMA), liver kidney microsome (LKM), thyroid microsome (TPO), and human thyroglobulin (TG). AAb status at baseline and during treatment was related to respective laboratory and clinical deviations. The analysis of AAb data included 355 patients receiving IFNbeta-1b and 353 receiving placebo. There was no difference between treatment groups in de novo AAb positivity. A greater proportion of women were AAb positive at baseline and during treatment. No association was found between liver enzyme elevations and ANA, AMA, or SMA antibody formation in either treatment group. Laboratory-based thyroid alterations during the study were significantly related to TG/TPO status at baseline but were not associated with IFNbeta-1b treatment. Adverse events possibly indicative of other diseases with autoimmune links were not associated with respective AAb status. Interferon beta-1b treatment did not induce autoantibody formation in this population of patients with secondary progressive multiple sclerosis.