Is There a Tendency for Autoimmunity in Neurofibromatosis Type 1? —Case Reports

Autoimmune diseases have been reported in association with neurofibromatosis type 1 (NF1) in adults. Two children with NF1 and concurrent autoimmune diseases: antimuscle-specific kinase antibody–positive myasthenia and juvenile idiopathic arthritis are reported. The possible mechanisms of autoimmuni...

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Bibliographic Details
Published inIndian journal of pediatrics Vol. 89; no. 5; pp. 510 - 512
Main Authors Esra, Serdaroglu, Ceren, Gunbey, Erdal, Sag, Hatice, Bektaş, Fatma, Esen, Banu, Anlar
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 01.05.2022
Subjects
Adult
Autoimmune Diseases - complications
Autoimmunity
Child
Clinical Brief
Gynecology
Humans
Medicine
Medicine & Public Health
Neurofibromatosis 1 - complications
Pediatrics
Autoimmunity
Neurofibromatosis type 1
Myasthenia
Pain, Association
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Summary:Autoimmune diseases have been reported in association with neurofibromatosis type 1 (NF1) in adults. Two children with NF1 and concurrent autoimmune diseases: antimuscle-specific kinase antibody–positive myasthenia and juvenile idiopathic arthritis are reported. The possible mechanisms of autoimmunity in NF1, particularly dysregulation in T lymphocyte proliferation and exposure to free DNA were discussed. In clinical practice, the possibility of a superposed disorder is to be considered, particularly on the background of a common clinical condition like NF1.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0019-5456
0973-7693
DOI:10.1007/s12098-021-04010-1