Studies on the preparation and properties of sol-gel molecularly imprinted polymer based on tetraethoxysilane for recognizing sulfonamides

• Published in: Journal of polymer research Vol. 17; no. 5; pp. 737 - 744
• Main Authors: Lee, Sung-Chuan, Chuang, Feng-Lin, Tsai, Yen-Ling, Chen, Hui
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2010; Springer Nature B.V
• Subjects: Calcination; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Competition; Imprinted polymers; Industrial Chemistry/Chemical Engineering; Optimization; Original Paper; Polymer Sciences; Recognition; Selectivity; Sol gel process; Tetraethoxysilane; Sulfamethoxazole; Sulfamethazine; Molecularly imprinted polymer; Sol-gel; HPLC
• ISSN: 1022-9760; 1572-8935
• DOI: 10.1007/s10965-009-9364-x

The synthesis of a molecularly imprinted polymer (MIP) composed of tetraethoxysilane (TEOS) for recognizing sulfonamides by sol-gel process is developed. The MIP’s preparation conditions, the H 2 O/Si molar ratios (R), pH value of the competition solution, and the calcination process are discussed. The competition experiments of the MIP for template (sulfamethazine, SMZ) and analogue (sulfamethoxazole, SMO) are performed by High-Performance Liquid Chromatography (HPLC). The results show that the selectivity of the competition solution with pH = 7.4 is higher than those with pH = 4.6. In addition, the selectivity of SMZ increases, while the calcination time and the calcination temperatures increase. Moreover, the selectivity of the MIP (53.3) is approximately seven times greater than that of the non-imprinted polymer (NIP) (8.32) under optimum preparation conditions.