Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population

• Published in: American journal of nephrology Vol. 54; no. 9-10; p. 359
• Main Authors: Yang, Wei-Shun, Chuang, Gwo-Tsann, Che, Tony Pan-Hou, Chueh, Li-Yun, Li, Wen-Yi, Hsu, Chih-Neng, Hsiung, Chia-Ni, Ku, Hsiao-Chia, Lin, Yi-Ching, Chen, Yi-Shun, Hee, Siow-Wey, Chang, Tien-Jyun, Chen, Shiau-Mei, Hsieh, Meng-Lun, Lee, Hsiao-Lin, Liao, Karen Chia-Wen, Shen, Chen-Yang, Chang, Yi-Cheng
• Format: Journal Article
• Language: English
• Published: Switzerland 01.11.2023
• Subjects: Albuminuria - epidemiology; Albuminuria - genetics; Genome-Wide Association Study; Glomerulonephritis, IGA; Humans; Kidney Function Tests; Polymorphism, Single Nucleotide; Renal Insufficiency, Chronic; Genome-wide association studies; Albuminuria; Nondiabetics
• ISSN: 1421-9670
• DOI: 10.1159/000531783

Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. Nondiabetic individuals aged 30-70 years without a history of cancer were enrolled from the Taiwan Biobank. A total of 6,768 subjects were subjected to a spot urine examination. After quality control using PLINK and imputation using SHAPEIT and IMPUTE2, a total of 3,638,350 single-nucleotide polymorphisms (SNPs) remained for testing. SNPs with a minor allele frequency of less than 0.1% were excluded. Linear regression was used to determine the relationship between SNPs and log urine albumin-to-creatinine ratio. Six suggestive loci are identified in or near the FCRL3 (p = 2.56 × 10-6), TMEM161 (p = 4.43 × 10-6), EFCAB1 (p = 2.03 × 10-6), ELMOD1 (p = 2.97 × 10-6), RYR3 (p = 1.34 × 10-6), and PIEZO2 (p = 2.19 × 10-7). Genetic variants in the FCRL3 gene that encode a secretory IgA receptor are found to be associated with IgA nephropathy, which can manifest as proteinuria. The PIEZO2 gene encodes a sensor for mechanical forces in mesangial cells and renin-producing cells. Five SNPs with a p-value between 5 × 10-6 and 5 × 10-5 are also identified in five genes that may have a biological role in the development of albuminuria. Five new loci and one known suggestive locus for albuminuria are identified in the nondiabetic Taiwanese population.