CATALYZED AND NON-CATALYZED SYNTHESIS OF BIOACTIVE MONASTROL

The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH...

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Published inQuímica Nova Vol. 37; no. 10; pp. 1713 - 1715
Main Authors Alvim, Haline G. O., Correa, Jose R., Machado, Taynara R., Silva, Wender A., Neto, Brenno A. D.
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 2014
Subjects
Biginelli
catalysis
Monastrol
multicomponent reaction
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Summary:The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.
ISSN:0100-4042
1678-7064
DOI:10.5935/0100-4042.20140266